Influence of the recipient's age on the effect of transplanting lymphoid organs from newborn donors |
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| Authors: | G M Butenko A I Kharazi I N Pishel' |
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| Affiliation: | Institute of Gerontology, Academy of Medical Sciences of the USSR, Kiev. |
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| Abstract: | The development of immunological capacity of newborn thymus and spleen grafted under the kidney capsule of different-age recipients was investigated. The grafts functions appear to depend strongly upon the macroenvironment of the organism where their development occurs. Therefore+ the favourable influence of young environmental factors, gradually decreasing with the recipient age to become immunosuppressive in old animals is obtained. These data indicate a predominant significance of the macroenvironmental factors both in maturation of the immune system and its alteration during aging. |
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