3H]muscimol binding sites increased in autopsied brains of chronic schizophrenics |
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| Authors: | S Hanada T Mita N Nishino C Tanaka |
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| Institution: | 1. Post Graduate Department of Biotechnology, Utkal University, Bhubaneswar 751014, Odisha, India;2. CSIR-Institute of Minerals & Materials Technology, Bhubaneswar 751013, Odisha, India;3. Academy of Scientific & Innovative Research, New Delhi 110025, India;4. Department of Biochemistry, North-Eastern Hill University, Shillong 792022, Meghalaya, India;1. Departamento de Bioquímica, Facultad de Ciencias, Universidad Antonio Nariño, sede circunvalar, Colombia;2. Departamento de Ciencias Básicas, Universidad Santo Tomás, Carrera 9 # 51-11, Bogotá, Colombia;3. Departamento de Química, Universidad de Los Andes, Cra 1 N° 18A – 12, Colombia;1. Helmholtz-Centre for Environmental Research – UFZ, Department of Environmental Biotechnology, Permoserstr, 15, 04318 Leipzig, Germany;2. School of Water Resources and Environment, China University of Geosciences, Beijing, Beijing 100083, PR China;3. RWTH Aachen University, Institute for Environmental Research, Worringerweg 1, 52074 Aachen, Germany |
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| Abstract: | 3H]muscimol binding and glutamic acid decarboxylase (GAD) activity in the prefrontal cortex and caudate nucleus of autopsied brains from 19 chronic schizophrenics and 17 control subjects were investigated. In the schizophrenics, saturation analysis with varying concentrations of 3H]muscimol revealed an increase in the number of GABAA receptors, but there was no significant difference in the affinity. In addition, the enhancement of 3H]muscimol binding by diazepam was significantly greater in schizophrenics than in controls. GAD activity did not differ between controls and schizophrenics. The possibility that GABAergic mechanisms might play a role in case of chronic schizophrenia should be given further attention. |
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