| Overexpression of γ-aminobutyric acid transporter subtype I leads to susceptibility to Kainic acid-induced seizure in transgenic mice |
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| 作者姓名： | MA YINGHUA JIA HUA HU WEN JUAN ZHAO JIAN FEI YUN YU XIAO GANG ZHOU ZHEN TONG MEI LI HE GUO |
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| 作者单位： | MA YINGHUA，JIA HUA HU，WEN JUAN ZHAO，JIAN FEI，YUN YU，XIAO GANG ZHOU，ZHEN TONG MEI，LI HE GUO (Institute of Biochemistry and Cell Biology，Shanghai Institutes for Biological Sciences，Chinese Academy of Sciences，Shanghai 200031，China |
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| 摘 要： | INTroDUCTION.7-aminobutyric acid (GABA), a major in-hibitory neurotransmitter in vertebrate brain, in--duces neuronal inhibition via GABA receptors. Adeficiency of GABAergic inhibition has been hy-pothesized to be a principal factor in the patho-genesis of epilepsy1]. GABA transporters are im-portant components of the GABAergic system, andfunction in part to terminate the GABA transmis-sion through rapid re-uptake of GABA into thepresynaptic neurons and surrounding gliaJ cells2…
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| 关 键 词： | γ-aminobutyric acid transporter seizure susceptibility kainic acid electroencephalography transgenic mice |
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