A radiation hybrid map spanning the entire human X Chromosome integrating YACs,genes, and STS markers |
| |
| Authors: | J. Kumlien A. Grigoriev H. Roest Crollius M. Ross P. N. Goodfellow H. Lehrach |
| |
| Affiliation: | (1) Department of Genome Analysis, Imperial Cancer Research Fund, P.O. Box 123, 44 Lincoln's Inn Fields, London WC2A 3 PX, UK, GB;(2) Department of Genetics, University of Cambridge, Cambridge, UK, GB |
| |
| Abstract: | We present a radiation hybrid (RH) map of human Chromosome (Chr) X, using 50 markers on 72 radiation hybrids. The markers, obtained from the consensus map, form a grid spanning the entire chromosome. To check the RH map, the marker order was determined by analysis of presence or absence of retained human DNA fragments in the RHs; the comparison with the consensus showed a similar order. Any STSs, microsatellites, genes, and clones can be positioned and ordered relative to the marker grid. This approach integrates genetic, physical, and large-scale clone mapping and is used to link YAC contigs containing data from various experimental sources. Received: 14 February 1996 / Accepted: 20 May 1996 |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
