Preparation and Evaluation of Microemulsion Systems Containing Salicylic Acid |
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| Authors: | Alia A Badawi Samia A Nour Wedad S Sakran Shereen Mohamed Sameh El-Mancy |
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| Institution: | (1) Pharmaceutics Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt;(2) Pharmaceutics Department, Faculty of Pharmacy, October 6 University, 6th of October, Egypt; |
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| Abstract: | Microemulsions (MEs) are clear, thermodynamically stable systems. They were used to solubilize drugs and to improve topical
drug availability. Salicylic acid (SA) is a keratolytic agent used in topical products with antimicrobial actions. The objective
of this work was to prepare and evaluate SA ME systems. Different concentrations of SA were incorporated in an ME base composed
of isopropyl myristate, water, and Tween 80: propylene glycol in the ratio of 15:1. Three ME systems were prepared: S2%, S5%, and S10% which contain 2%, 5%, and 10% of SA, respectively. Evaluation by examination under cross-polarizing microscope, measuring
of percent transmittance, pH measurement, determination of the specific gravity, assessment of rheological properties, and
accelerated stability study were carried out. The data showed that the addition of SA markedly affected the physical properties
of the base. All systems were not affected by accelerated stability tests. Stability study for 6 months under ambient conditions
was carried out for S10%. No remarkable changes were recorded except a decrease in the viscosity value after 1 month. The results suggested that ME
could be a suitable vehicle for topical application of different concentrations of SA. |
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