Role of nuclear factor-kappaB in providing interactions of human neutrophils and epithelial cells from oral cavity with Candida albicans

Contribution of intracellular signal pathways associated with nuclear factor kappaB (NF-kappaB) in realization of interactions of human neutrophils and epithelial cells from oral cavity with Candida albicans was studied. Supression of NF-kappaB in epitheliocytes resulted in decreased adsorption of C. albicans to buccal cells (buccal mucosa). Inhibition of NF-kappaB led to decrease in receptor-dependent oxidative activity of neutrophils in systems with native and IgG-opsonized C. albicans as well as to increase of phagocytic activity during contact with C3b-/iC3b-opsonized C. albicans. It has been concluded that NF-kappaB participates in regulation of specific interactions of neurophils and epitheliocytes with C. albicans.