Resolution of 2-cyano-2-methylalkanoic acids via porcine pancreatic lipase-catalyzed enantioselective ester hydrolysis: effect of the alcohol moiety of the substrate ester on enantioselectivity |
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| Authors: | Toshifumi Miyazawa Masanori Shimaoka Takashi Yamada |
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| Affiliation: | (1) Department of Chemistry, Faculty of Science, Konan University, Higashinada-ku, Kobe, 658-8501, Japan |
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| Abstract: | 2-Cyano-2-methylalkanoic acids were resolved via porcine pancreatic lipase-catalyzed enantioselective ester hydrolysis. The importance of the alcohol moiety of the substrate ester on enantioselectivity was confirmed: the E value was increased up to 9-fold by using the n-butyl ester instead of the conventional methyl ester. The maximum E value was 180. |
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| Keywords: | enantioselectivity ester hydrolysis optical resolution porcine pancreatic lipase 2-cyano-2-methylalkanoic acids |
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