Interrelationships between gluconeogenesis and uricogenesis in chicken liver |
| |
| Affiliation: | 1. Hunter College and City University of New York, USA;2. University of Wisconsin-Madison, USA;3. Johns Hopkins University, USA;1. College of Geography and Environmental Science, Northwest Normal University, Lanzhou 730070, China;2. Cryosphere Research Station on the Qinghai-Tibetan Plateau, State Key Laboratory of Cryospheric Science, Northwest Institute of Eco-Environment and Resources, Chinese Academy of Sciences, Lanzhou 730070, China;3. University of Chinese Academy Sciences, 19(A) Yuquan Road, Shijingshan District, Beijing, 100049, China. |
| |
| Abstract: | - 1.1. Experiments performed on isolated hepatocytes and perfused liver of starved chickens showed that gluconeogenesis from lactate, glycerol and fructose was inhibited by 22–100% on addition of urate precursors.
- 2.2. The inhibition was associated with an increased rate of urate formation.
- 3.3. 2,4-Dinitrophenol (40 μM), 2-bromooctanoate (2 mM) and 3-mercaptopicolinate (3MPA) (0.5 mM) were inhibitory with respect to gluconeogenesis but did not significantly affect the rate of urate formation.
- 4.4. The possible interrelationships between gluconeogenesis and uricogenesis are considered in terms of a competition for ATP and for other metabolites between the two pathways.
- 5.5. An interplay of both pathways at the level of anion transfer across the inner mitochondrial membrane is also discussed.
|
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
