Restoring the biological activity of crizanlizumab at physiological conditions through a pH-dependent aspartic acid isomerization reaction |
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| Authors: | Fabian Bickel,Franç ois Griaud,Wolfram Kern,Frieder Kroener,Manuela Gritsch,Jé rô me Dayer,Samuel Barteau,Blandine Denefeld,Chi-Ya Kao-Scharf,Manuel Lang,Izabela Slupska-Muanza,Carla Schmidt,Matthias Berg,Jü rgen Sigg,Lina Boado,Dirk Chelius |
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| Affiliation: | Analytical Development, Technical Research and Development Biologics, Novartis Pharma AG, Basel, Switzerland |
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