Metabolism of the polycyclic aromatic hydrocarbon pyrene by Aspergillus niger SK 9317 |
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| Authors: | T. Wunder S. Kremer O. Sterner H. Anke |
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| Affiliation: | (1) Department of Biotechnology, University of Kaiserslautern, Paul-Ehrlich-Strasse 23, D-67663 Kaiserslautern, Germany;(2) Department of Organic Chemistry 2, Chemical Center, University of Lund, P.O. Box 124, S-211 00 Lund, Sweden |
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| Abstract: | The metabolism of pyrene, a polycyclic aromatic hydrocarbon consisting of four rings, by Aspergillus niger SK 9317 was investigated. The metabolites formed were isolated and identified as 1-hydroxypyrene, 1,6- and 1,8-pyrenequinone, 1,6- and 1,8-dihydroxypyrene, 1-pyrenyl sulphate and 1-hydroxy-8-pyrenyl sulphate. This is the first report of 1-hydroxy-8-pyrenyl as a metabolite in the microbial metabolism of pyrene. The results suggest that A. niger metabolizes pyrene by cytochrome P-450 monooxygenase enzyme systems. |
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