Synthesis and biological evaluation of novel selenonucleosides |
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Authors: | Chen Yao Peng Yingdan Zhang Jiancun Fu Lei |
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Affiliation: | School of Pharmacy, Shanghai Jiaotong University, Shanghai, PR China. |
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Abstract: | A series of novel selenonucleoside analogues with 1,4-oxaselenane as the carbohydrate fragment has been synthesized from their corresponding dimesylated seconucleosides treated with NaHSe solution and subsequent deprotection. The synthesized selenonucleoside analogues were evaluated as potential antitumor agents. |
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