Production of L-Phenylacetyl Carbinol by Immobilized Cells of Saccharomyces Cerevisiae |
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Authors: | A.K. Mandwal C.K.M. Tripathi P.D. Trivedi A.K. Joshi S.C. Agarwal Vinod Bihari |
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Affiliation: | Division of Fermentation Technology, Central Drug Research Institute, Lucknow 226 001, India. |
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Abstract: | Conversion of benzaldehyde to L-phenylacetyl carbinol (L-PAC) was achieved with immobilized, growing cells of Saccharomyces cerevisiae in different reactors. Product formation increased (31%) with the subsequent initial reuses of the entrapped cells. Biomass production and PAC formation depleted (40 and 57%, respectively) after 4-5 continuous growth and biotransformation cycles. With the regeneration of the biocatalysts, catalytic activity of the cells was resumed. The highest yields were in a stirred tank reactor (29 g PAC) from 77 g benzeldehyde with 14 repeated uses of entrapped cells. |
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Keywords: | benzaldehyde biotransformation immobilized biocatalysts reactor |
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