Design, synthesis and preliminary biological evaluation of a focused combinatorial library of stereodiverse carbohydrate-scaffold-based peptidomimetics |
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| Authors: | Moitessier N Dufour S Chrétien F Thiery J P Maigret B Chapleur Y |
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| Institution: | Groupe SUCRES, Unité Mixte 7565 CNRS-Université Henri Poincaré-Nancy 1, Nancy-Vandoeuvre, France. |
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| Abstract: | A focused combinatorial library of 126 mimetics of the RGD sequence based on sugar scaffolds have been rationally constructed using molecular modeling, with a particular emphasis on the stereodiversity of the library. A liquid phase, mix and divide synthesis was used, active compounds being identified by using orthogonal libraries and recursive deconvolution strategies. |
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