Gentamicin resistance in clinical strains ofEnterobacteriaceae associated with reduced gentamicin uptake |
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Authors: | K Adwan N Abu-Hasan |
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Institution: | (1) Department of Biological Sciences, An-Najah N. University, Nablus, Palestine |
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Abstract: | Seven strains ofEnterobacteriaceae resistant to gentamicin obtained as representatives of the predominant resistance profiles in the clinical laboratories ofRafeidia and Al-Watani Hospitals in Nablus (Palestine) were included. Five strains showed a broad aminoglycoside resistance profile but contained no evidence
of gentamicin acetylation, adenylation, or phosphorylation. Gentamicin uptake in two tested strains was significantly reduced,
compared to that of gentamicin-sensitiveE. coli (MIC, 0.5 μg/mL.) These strains are likely resistant due to a relative reduction of the amount of gentamicin and other aminoglycosides
entering the bacterial cell. Two strains showed evidence of adenyltransferase ANT (2")-I activity. |
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