多巴胺D2受体在肿瘤治疗中的研究进展

多巴胺(Dopamine)(C6H3(OH)2-CH2-CH2-NH2)是人类中枢神经系统的重要儿茶酚胺类神经递质,通过其相应的膜受体而发挥情绪、饮食、运动、认知及外周血等的调节作用。多巴胺受体属于膜G蛋白偶联受体家族。目前发现的多巴胺受体有五种,其中D2受体基因主要分布于脑部。近年来的研究表明,多巴胺D2受体对肿瘤细胞具有抑制作用,对肿瘤的药物治疗具有重要意义。目前,D2受体激动剂已经成为大多数泌乳素瘤的首选治疗药物。本文通过文献回顾,对多巴胺受体在肿瘤的预后和治疗中的作用进行综述。

Progress of Dopamine D2 Receptor in the Treatment of Carcinoma

Dopamine (C6H3 (OH) 2-CH2-CH2-NH2) is the important catecholamine neurotransmitter of human central nervous system which could regulate the emotion, diet, exercise, cognitive and peripheral blood by its receptors. Dopamine receptors belong to the membrane G protein coupled receptor family. As so far, five kinds of dopamine receptors have confirmed, in which the mainly distributed in the brain is D2 receptor gene. Recent researches have shown that the dopamine D2 receptor would play an important role in tumor prognosis by inhibiting the proliferation of tumor cells. Nowadays, the D2 receptor agonists have become the first choice in the treatment of prolactinoma. This paper aims to review the research progress of dopamine receptors in the cancers.