肿瘤坏死因子alpha与子痫前期的关系

子痫前期是妊娠期特有疾病，是导致孕产妇及围生儿病死率的重要原因，其病因和发病机理仍未完全明确。目前，已被提出 和子痫前期的发生相关的因素包括遗传、氧化应激、异常滋养层细胞侵入、血管内皮细胞功能紊乱、营养缺乏、免疫缺陷等，其中 内皮细胞损伤导致的内皮细胞生理功能紊乱已经成为子痫前期病因学研究的热点。肿瘤坏死因子-alpha(tumor necrosis factor-alpha， TNF-alpha)在内皮细胞损害中发挥着重要作用，可能通过诱导炎性因子和血管内皮细胞黏附分子-1(VCAM-1)生成、抑制基质金属蛋 白酶(MMP)、影响血管活性物质、脂联素、瘦素和血管因子生成，介导子痫前期的发生。本文就TNF-琢与子痫前期发生的关系进行 综述。

The Relationship between Tumor Necrosis Factor-alpha and Preeclampsia

Preeclampsia (PE) is a prevalent life-threatening hypertensive disorder of pregnancy and also a major cause of maternal and perinatal morbidity and mortality. Although the etiology of preeclampsia remains unknown. Now, there are many proposed theories regarding the pathogenesis of the preeclamptic disease processes such as genetic predisposition; oxidative stress; abnormal trophoblast invasion; vascular endothelial dysfunction; dietary deficiencies and defective immunological adaptation to pregnancy and so on. Endothelial cell dysfunction caused by endothelial cell injury is a hot issue of etiology research. TNF-alpha plays an important role in the damage of endothelial cell, possibly by guiding inflammatory cytokines and VCAM-1 production, inhibiting MMP, effecting vasoactive substances, adiponectin, leptin and vascular factor production, which may be mediated to the occurrence of preeclampsia. This article is aimed to review the relationship between TNF-alpha and preeclampsia.