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Energy Profile of the Space of Model Protein Sequences |
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| Authors: | G. Tiana R.A. Broglia E.I. Shakhnovich |
| Affiliation: | (1) The Niels Bohr Institute, University of Copenhagen, Bledgamsvej 16, 2100 Copenhagen, Denmark;(2) Dipartimento di Fisica, Universitá di Milano and INFN, sezione di Milano, via Celoria 16, 20133 Milano, Italy;(3) Department of Chemistry, Harvard University, 16 Oxford st., Cambridge, MA, USA |
| Abstract: | A numerical study of the energy landscape of the space of model proteinsequences is carried out. As a consequence of the heterogeneity of thecontact energies among amino acids, the energy landscape displays a veryrough profile, a behaviour typical of frustrated systems. This givesraise to a hierarchical clustering of low-energy sequences and can have evolutionary consequences. |
| Keywords: | energy landscapes model protein space of sequences |
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