Modification of urinary secretion of 8-hydroxy-2'-deoxyguanosine and serum ACTH concentration following repetitive parabolic flights |
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Authors: | Nomura J Arase Y Sugaya S Moriya T Chen Z Takahashi S Kita K Kikuno K Nomura F Suzuki N |
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Affiliation: | Department of Environmental Biochemistry, Chiba University, Chiba, Japan. |
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Abstract: | It is important to clarify the molecular mechanisms of physiological responses of the human body to changes in gravity. Previous reports demonstrated that gravity-changing stress increases the human urinary concentration of 8-hydroxy-2'-deoxyguanosine (8-OHdG). However, it has yet to be clarified whether repetitive parabolic flight modulates the urinary concentration of 8-OHdG after exposure to gravity-changing stress. In the present study, the effects of the number of previous experiences with parabolic flight on urinary excretion of 8-OHdG and concentration of serum ACTH were examined in 12 healthy volunteers. |
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