Mitotic activity of gonadotropes in the anterior pituitary of the castrated male rat |
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| Authors: | Dr Kinji Inoue Shigeyasu Tanaka Kazumasa Kurosumi |
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| Institution: | (1) Department of Morphology, Institute of Endocrinology, Gunma University, Gunma, Japan;(2) Institute of Endocrinology, Gunma University, Maebashi, 371 Gunma, Japan |
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| Abstract: | Summary The proliferation of gonadotropes in the anterior pituitary of the castrated male rat was examined immunohistochemically after colchicine treatment. The results show a more than 10-fold increase in mitotic frequency in gonadotropes 1 or 2 weeks after castration, as compared with controls. This result explains the increase in the population of immunoreactive LH cells in castrated male rats. The gonadotropes decreased significantly 1 month after castration. The mitotic activity of gonadotropes was almost completely suppressed in castrates implanted with a silastic tube filled with testosterone. |
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| Keywords: | Pituitary Castration Gonadotropes Mitosis Testosterone replacement Rat |
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