Factor XIII Val34Leu polymorphism and risk of recurrent pregnancy loss in Iranian population: a case control study |
| |
| Authors: | Seyed Mehdi Sajjadi Abbas Khosravi Jalil Pakravesh Zahra-soheila Soheili Shahram Samiei Saeed Mohammadi Mohammad Ali Jalali far |
| |
| Affiliation: | 1.Cellular and Molecular Research Center of Birjand University of Medical Sciences,Biriand,Iran;2.Department of Hematology,Tehran University of Allied Medical Sciences,Tehran,Iran;3.Department of Obstetrics and Gynecology,Aban General Hospital,Tehran,Iran;4.Cellular and Molecular Biology,National Institute of Genetic Engineering and Biotechnology,Tehran,Iran;5.Blood Transfusion Research center,High Institute for Research and Education in Transfusion Medicine,Tehran,Iran;6.Hematology Oncology and Stem Cell Translantation Research Center,Tehran University of Medical Sciences,Tehran,Iran;7.Health research institute, Research Center of Thalassemia & Hemoglobinopathy,Ahvaz Jundishapur University of Medical Sciences,Ahvaz,Iran |
| |
| Abstract: | BACKGROUNDRecurrent pregnancy loss (RPL) is a heterogeneous condition and thrombophilias have been considered as a probable cause.OBJECTIVEThe aim of this study was to investigate the prevalence of the coagulation factor XIII Val34Leu polymorphism among women with unexplained RPL.METHODSA total of 140 women with a history of unexplained RPL and 100 age-matched healthy fertile women were recruited. The presence of FXIII Val34Leu polymorphism among the cases and controls was investigated using PCR-RFLP method.RESULTSGenotype analyses of the subjects revealed that the patients had a significantly higher prevalence of V/L and L/L than the controls (P<0.05): 33.5% vs. 15%, and 9.2% vs. 2%, respectively.CONCLUSIONThese results indicate a significant association between FXIII Val34Leu polymorphism and unexplained RPL in the Iranian patient. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
