Enhancingin vitro antibody production rate per cell by applying mouse peritoneal factors |
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Authors: | T. Mikami F. Makishima E. Suzuki |
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Affiliation: | (1) Department of Chemical Engineering, University of Tokyo, 7-3-1 Hongo, Bunkyo-Ku, 113 Tokyo, Japan |
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Abstract: | Summary Monoclonal antibody production rateper hybridoma cell was measured as much larger in mouse peritoneal cavity thanin vitro culture. To identify factors enhancing antibody productivity per cell, a hybridoma was culturedin vitro with ascites and peritoneal exudate cells(PEC). Both the ascites and the PEC improved the productivity per cellin vitro. Each chromatograph-fraction of ascites was assayed for the enhancing activity. |
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