Antihyperglycemic activity of herb extracts on streptozotocin-induced diabetic rats |
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| Authors: | Jung Chang Hwa Zhou Song Ding Guo Xun Kim Ji Hye Hong Myung Hee Shin Yong-Cheol Kim Gyung Jun Ko Seong-Gyu |
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| Institution: | Laboratory of Clinical Biology and Pharmacogenomics, College of Oriental Medicine, Kyunghee University, South Korea. |
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| Abstract: | We investigated the effects of herb extracts, Rhus verniciflua, Agrimonia pilosa, Sophora japonica, and Paeonia suffruticosa, on the lowering of blood glucose levels and thiobarbituric acid reactive substances (TBARS) in streptozotocin (STZ)-induced diabetic rats. After 4 weeks, oral administration of Rhus verniciflua extract (50 mg/kg) exhibited a significant decrease in blood glucose levels in diabetic rats (P<0.05). Blood TBARS concentrations, the products of glucose oxidation in blood, were also lowered by Rhus verniciflua extract supplementation. In addition, Sophora japonica and Paeonia suffruticosa extracts significantly reduced TBARS levels versus diabetic controls. Serum concentrations of liver-function marker enzymes, GOT and GPT, were also restored by Rhus verniciflua (50 mg/kg) supplementation in diabetic rats. |
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