The effects of alcohol on cyclic AMP in mouse brain |
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Authors: | E. K. Orenberg J. Renson J. D. Barchas |
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Affiliation: | (1) Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 94305 Stanford, California |
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Abstract: | Detailed analysis of the dose-response and time-course relationship of ethanol to changes in adenosine 3,5-cyclic monophosphate (cAMP) content of mouse brain revealed several patterns of response, including both decreases and increases depending on brain area. Whole-brain cAMP content was decreased with ethanol injection at all doses (0.4–3.2 g/kg), and reflected the decreased levels in the cortex. The subcortical and cerebellar levels underwent a significant increase with doses of 1.6 and 3.2 g/kg, respectively. In all brain areas, significant changes in cAMP content occur within 10 min after ethanol injection; elevated levels persist for 30–60 min in the subcortex and cerebellum, but remain significantly depressed in the cortex at 3 h. These dynamic changes in brain cAMP levels after ethanol administration may reflect variations in neurotransmitter activity. |
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