| 蛋白质内含肽及其生物学意义 |
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| 引用本文： | 李素丽,郑斌,詹希美.蛋白质内含肽及其生物学意义[J].生物技术通讯,2005,16(5):552-555. |
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| 作者姓名： | 李素丽 郑斌 詹希美 |
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| 作者单位： | 中山大学,中山医学院寄生虫学教研室,广东,广州,510089 |
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| 摘 要： | 蛋白质内含肽是存在于前体蛋白质中的一段多肽链，靠自我剪切的方式从前体蛋白中释放出来。蛋白质内含肽的发现，不仅在理论上丰富了遗传信息翻译后加工的内容，而且在实践上有重大的生物学意义，特别是在蛋白质纯化方面有着广泛的应用前景。本文就蛋白质内含肽的发现、特征、鉴定、剪接机制及其生物学意义作一概述。
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| 关 键 词： | 蛋白质内含肽 蛋白质外显肽 蛋白剪接 归巢核酸内切酶 |
| 文章编号： | 1009-0002(2005)05-0552-04 |
| 收稿时间： | 02 28 2005 12:00AM |
| 修稿时间： | 2005年2月28日 |
Inteins and its Biological Significance |
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| LI Su-li,ZHENG Bin,ZHAN Xi-mei.Inteins and its Biological Significance[J].Letters in Biotechnology,2005,16(5):552-555. |
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| Authors: | LI Su-li ZHENG Bin ZHAN Xi-mei |
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| Institution: | Department of Parasitology, Zhongshan Medical College, Sun Yat-sen University, Guangzhou 510089, China |
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| Abstract: | Inteins are internal segment peptides existing in precursor proteins, which could be excised from a precursor protein by self-cleavage.Its discovery not only enriches the content of the process that the gene transfers its information but also has great significance in practice, especially has a wide application prospect in protein purification. In this review, the discovery, characteristics, identification, splicing mechanism of inteins and its biological significance were summarized. |
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| Keywords: | intein extein protein splicing homing endonuclease |
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