Anti-inflammatory cyathane diterpenoids from Sarcodon scabrosus |
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Authors: | Kamo Tsunashi Imura Yuki Hagio Tomomi Makabe Hidefumi Shibata Hisao Hirota Mitsuru |
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Institution: | Department of Bioscience and Biotechnology, Faculty of Agriculture, Shinshu University, Gifu, Japan. |
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Abstract: | Four novel diterpenoids were isolated from the fruiting bodies of Sarcodon scabrosus (Fr.) Karst. (Boraginaceae) together with neosarcodonin A. One of the novel compounds was elucidated to be a cyathane diterpenoid, namely neosarcodonin O, by its spectral data. The others were characterized as 19-O-linoleoyl, 19-O-oleoyl and 19-O-stearoyl derivatives of sarcodonin A, after comparison with the authentic samples synthetically prepared from sarcodonin A. These compounds, together with the five 19-O-acyl derivatives synthesized from sarcodonin A, each exhibited inhibitory activity against 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation on mouse ears by topical application. |
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