Surface plasmon resonance mass spectrometry: recent progress and outlooks |
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Authors: | Nedelkov Dobrin Nelson Randall W |
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Institution: | Intrinsic Bioprobes, 625 South Smith Rd, Suite 22, Tempe, AZ 85281, USA. dnedelkov@intrinsicbio.com |
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Abstract: | The combination of surface plasmon resonance (SPR) and mass spectrometry (MS) has created a unique approach to protein investigations. Surface plasmon resonance is used to quantify interactions between proteins and surface-immobilized ligands, and MS is used to determine the structural features of the bound proteins. Recent progress in SPR-MS includes improved methods and operations, increased limits of detection, multi-protein analysis and protein-complex delineation. With the subsequent design of SPR protein arrays, SPR-MS is expected to enter into the field of high-throughput protein interaction discovery and miniaturized diagnostics. |
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