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Ultrastructural identification of monoaminergic synaptosomes from one day old rat brain |
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| Authors: | Lasse Kanerva Antti Hervonen Anja H. Tissari |
| Affiliation: | (1) Department of Human Anatomy, University of California, Davis, USA;(2) Institute of Biomedical Sciences, University of Tampere, Teiskontie 37, SF-33520 Tampere 52, Finland;(3) Department of Pharmacology, University of Helsinki, Siltavuorenpenger 10, SF-00170 Helsinki 17, Finland |
| Abstract: | Summary Synaptosomes from one day old and adult rat brain were studied. Specific cytochemical methods for demonstrating monoaminergic (MA) nerve endings were used. Permanganate fixation after preincubation with 5-OHDA or  -methyl-NA demonstrated MA synaptosomes. Their number was small in the adult (less than 1%) and still smaller in the one day old rat brain. The MA synaptosomes from developing rats were different from the adult ones. The large amount of endoplasmic reticulum in developing synaptosomes suggests that granular vesicles are formed from endoplasmic reticulum in nerve endings. |
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