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Retention of gold nanoparticles in the structure of quasinematic layers formed by DNA molecules |
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| Authors: | S G Skuridin V A Dubinskaya E V Shtykova V V Volkov V M Rudoy O V Dement’eva V A Kuzmin E S Lisitsyna S T Zakhidov I A Zelenina Yu M Yevdokimov |
| Institution: | 1. Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, ul. Vavilova, 32, Moscow, 119991, Russia 2. Scientific-Research and Education-Methodological Centre of Biomedical Technologies of the Russian Institute for Medicinal and Aromatic Herbs, Russian Academy of Agricultural Sciences, ul. Krasina, 2, Moscow, 123056, Russia 3. Shubnikov Institute of Crystallography, Russian Academy of Sciences, Leninskii prosp., 59, Moscow, 119333, Russia 4. Frumkin Institute of Physical Chemistry and Electrochemistry, Russian Academy of Sciences, Leninskii prosp., 31, Moscow, 119991, Russia 5. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, ul. Kosygina, 4, Moscow, 117997, Russia 6. Biological Faculty, Moscow Lomonosov State University, Leninskie gory, 1, build. 12, Moscow, 119991, Russia |
| Abstract: | Gold nanoparticles are shown to get incorporated into double-stranded DNA molecules forming quasinematic layers in the cholesteric liquid-crystalline dispersion particles. The process of nanoparticle incorporation results in distortion in an ordered arrangement of the neighboring dsDNA molecules in a layer and in global spatial structure of particles of the dispersion, which may be one of the possible causes of the genotoxicity of gold nanoparticles. |
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