Identification of PGC7, a new gene expressed specifically in preimplantation embryos and germ cells |
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| Authors: | Sato Masatake Kimura Tohru Kurokawa Ken Fujita Yukiko Abe Koichiro Masuhara Masaaki Yasunaga Teruo Ryo Akihide Yamamoto Mikio Nakano Toru |
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| Affiliation: | Department of Molecular Cell Biology, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamada-oka Suita 565-0871, Japan. |
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| Abstract: | The gene expression patterns of primordial germ cells (PGCs) and embryonic stem cells were analyzed by a modified serial analysis of gene expression. During the process, we cloned a novel gene, PGC7, which was preferentially expressed in PGCs. Immunohistochemical analysis revealed that PGC7 was specifically expressed in early pre-implantation embryos, PGCs and oocytes. These results suggest that PGC7 might play an important role in the development of PGCs and oocytes. |
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