Oligonucleotides containing 7-vinyl-7-deazaguanine as a facile strategy for expanding the functional diversity of DNA |
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| Authors: | Okamoto Akimitsu Taiji Toshiji Tainaka Kazuki Saito Isao |
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| Affiliation: | Department of Synthetic Chemistry and Biological Chemistry, Faculty of Engineering, Kyoto University, SORST, Japan Science and Technology Corporation, Japan. |
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| Abstract: | A modified nucleobase 7-vinyl-7-deazaguanine ((V)G) produced adducts with maleimides through Diels-Alder cycloaddition under very mild conditions. By this method, post-synthetic modification to oligonucleotides with diverse functionality (carboxylic acid, pyrene, benzophenone, succinimidyl ester, nitroxide and biotin) was accomplished. |
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