Single-nucleotide polymorphism <Emphasis Type="Italic">rs</Emphasis>11562975 of the thermosensitive ion channel <Emphasis Type="Italic">TRPM</Emphasis>8 gene and human sensitivity to cold and menthol |
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| Authors: | T V Kozyreva E Ya Tkachenko T A Potapova A G Romashchenko M I Voevoda |
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| Institution: | 1.Institute of Physiology, Siberian Branch,Russian Academy of Medical Sciences,Novosibirsk,Russia;2.Institute of Cytology and Genetics, Siberian Branch,Russian Academy of Medical Sciences,Novosibirsk,Russia;3.Institute of Therapy, Siberian Branch,Russian Academy of Medical Sciences,Novosibirsk,Russia |
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| Abstract: | The examination of subjects from the Russian ethnic group revealed that 20.3% of them had the heterozygous genotype containing
the C-allele in the rs11562975 (G → C) single-nucleotide polymorphism located in exon 7 of the gene encoding the temperature-sensitive ion channel TRPM8. Functional differences associated with the sensitivity to cold and menthol were revealed in subjects with different rs11562975 polymorphism genotypes (GG and GC). The subjects with the heterozygous genotype GC were characterized by increased sensitivity to cold and decreased sensitivity to menthol, an agonist of the ion channel TRPM8, compared to the subjects with the homozygous genotype GG |
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