Stimulation of insulin secretion by transforming growth factor-beta |
| |
| Authors: | Y Totsuka M Tabuchi I Kojima Y Eto H Shibai E Ogata |
| |
| Institution: | Fourth Department of Internal Medicine, University of Tokyo School of Medicine, Japan. |
| |
| Abstract: | Effects of transforming growth factor-beta (TGF-beta) on insulin secretion were studied in rat pancreatic islets. When islets were incubated in a batch incubation system with various concentrations of TGF-beta in the presence of 2.8 mM glucose, TGF- beta increased insulin release in a concentration-dependent manner. Both TGF- beta 1 and TGF- beta 2 were equally effective. The stimulatory action of TGF- beta was greater in the presence of stimulatory concentration of glucose. In perifusion system, TGF- beta induced an immediate monotonic increase in insulin secretion. These results indicate that TGF- beta is a stimulator of insulin secretion. |
| |
| Keywords: | |
|
|
