Parental origin of chromosome abnormalities in spontaneous abortions |
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Authors: | Gitta H M Meulenbroek Joep P M Geraedts |
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Institution: | (1) Department of Human Genetics, Sylvius Laboratories, State University, P. O. Box 9503, NL-2300 RA Leiden, The Netherlands |
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Abstract: | Summary Tissue cultures were initiated from 130 spontaneous abortion specimens and 81 were successfully karyotyped. Chromosome abnormalities were found in 50 cases: 12 with XO, 27 with trisomy, 6 with triploidy, 1 with tetraploidy and 4 others. The parental origin was determined in 11 cases of trisomy for an acrocentric chromosome. Two cases were uninformative while 9 non-disjunctions were determined and occurred during meiosis I: 7 were maternal and 2 paternal (both with trisomy 21). Three out of 7 cases with trisomy 16 were informative and resulted from a divisional error during the first meiotic division in the mother. All cases of triploidy were informative. They resulted from non-reduction during meiosis I in the mother (2) or dispermy (4). |
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