Localization of the nucleotide excision repair gene ERCC6 to human chromosome 10q11-q21. |
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| Authors: | C Troelstra R M Landsvater J Wiegant M van der Ploeg G Viel C H Buys J H Hoeijmakers |
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| Institution: | Department of Cell Biology and Genetics, Erasmus University Rotterdam, The Netherlands. |
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| Abstract: | We have cloned the human DNA excision repair gene ERCC6 by virtue of its ability to correct the uv sensitivity of Chinese hamster overy cell mutant UV61. This mutant is a member of complementation group 6 of the nucleotide excision repair-deficient rodent mutants. By means of in situ hybridization and Southern blot analysis of mouse x human somatic cell hybrids, the gene was localized to human chromosome 10q11-q21. An RFLP detected within the ERCC6 locus can be helpful in linkage analysis. |
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