Serum esterase activities and hyperlipidaemia in the streptozotocin -diabetic rat |
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| Authors: | Bhartiben N Patel Michael I Mackness Derek W Harty Sharon Arrol Raymond P Boot-Hanford Paul N Durrington |
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| Institution: | 1. Department of Biochemistry and Molecular Biology, University of Manchester Medical School, Mancester, U.K.;2. Department of Medicine, University of Manchester Medical School, Manchester, U.K. |
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| Abstract: | The levels of activity of four serum esterases were measured in control and streptozotocin-diabetic rats for a period of 6 months. Pseudocholinesterase activity was significantly elevated in the diabetic rats at all points tested, reaching 250% of control activity at 6 months. Levels of paraoxonase activity progressively decreased with time in the diabetic rats, being 36% lower than in controls at 6 months. No significant differences in either serum arylesterase or carboxylesterase activity between control and diabetic rats were observed. |
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| Keywords: | Serum esterase Hyperlipidaemia Diabetes (Rat) |
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