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Physiologic levels of salivary epidermal growth factor stimulate migration of an oral epithelial cell line |
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| Authors: | Leah S Royce Bruce J Baum |
| Institution: | Laboratory of Developmental Biology and Anomalies, and Clinical Investigations and Patient Care Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, MD U.S.A. |
| Abstract: | An established line of human oral epithelial cells exhibits chemotaxis to epidermal growth factor (EGF). The directed migration of these cells is time dependent with an approximate 10-fold increase in the number of cells responding to the chemoattractant by 6 h. Cell migration occurs in a concentration dependent manner with maximal response at ≈ 1 ng/ml. This maximal chemotactic response occurs within the physiologic concentration range for EGF found in human saliva. These data suggest that EGF may be important for the maintenance of an intact oral epithelial (mucosal) barrier, and may play a vital role in oral mucosal wound healing. |
| Keywords: | Epidermal growth factor Chemotaxis Saliva (Human oral epithelial cell line) EGF epidermal growth factor TGFβ transforming growth factor β BSA bovine serum albumin bFGF basic fibroblast growth factor MEM minimal essential medium PDGF platelet-derived growth factor |
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