The structure of duplex DNA in the nucleosome core particle: An alternative model |
| |
| Authors: | A T Baker V Mckee G A Rodley |
| |
| Institution: | (1) Department of Chemistry, University of Technology Sydney, P O Box 123, 2007 Broadway, NSW, Australia;(2) Department of Chemistry, University of Canterbury, Christchurch, New Zealand;(3) Department of Pharmacy, University of Sydney, 2006 Sydney, NSW, Australia;(4) C/o Director, Centre for Cellular and Molecular Biology, 500 007 Hyderabad, India |
| |
| Abstract: | Many studies indirectly indicate that the conformation ofin vivo duplex DNA is the double helix. The most direct view, from the X-ray analysis of the nucleosome core particle, has also been
interpreted in terms of the double helix structure. However, an alternative possibility exists; that the duplex adopts a metastable
side-by-side conformation which readily converts to the double helix on removal of protein. Evidence for the existence of
this conformation has been obtained from a reanalysis of the electron density map for the nucleosome particle. |
| |
| Keywords: | Chromatin nucleosome DNA conformation X-ray electron-density |
| 本文献已被 SpringerLink 等数据库收录！ |
|
