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Bioorganic synthesis of end-capped anti-HIV peptides by simultaneous cyanocysteine-mediated cleavages of recombinant proteins |
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| Authors: | Michinori Tanaka Kazumi Kajiwara Rei Tokiwa Kentaro Watanabe Hiroaki Ohno Hiroko Tsutsumi Yoji Hata Kazuki Izumi Eiichi Kodama Masao Matsuoka Shinya Oishi Nobutaka Fujii |
| Affiliation: | aGraduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan;bJST Innovation Plaza Kyoto, Japan Science and Technology Agency, Nishigyo-ku, Kyoto 615-8245, Japan;cGekkeikan Research Institute, Gekkeikan Sake Company, Ltd, Fushimi-ku, Kyoto 612-8391, Japan;dInstitute for Virus Research, Kyoto University, Sakyo-ku, Kyoto 606-8507, Japan |
| Abstract: | Bioorganic synthesis of N- and C-terminal end-capped peptides by two simultaneous S-cyanocysteine-mediated cleavages of recombinant proteins is described. This approach is demonstrated in the preparation of anti-HIV fusion inhibitory peptides. |
| Keywords: | Bioorganic synthesis End-capped peptide Fusion inhibitor HIV-1 |
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