Sigma-1 receptor antagonist haloperidol attenuates Ca2+ responses induced by glutoxim and molixan in macrophages |
| |
Authors: | Z. I. Krutetskaya L. S. Milenina A. A. Naumova S. N. Butov V. G. Antonov A. D. Nozdrachev |
| |
Affiliation: | 1.St. Petersburg State University,St. Petersburg,Russia |
| |
Abstract: | Using Fura-2AM microfluorimetry, we have shown for the first time that sigma-1 receptor antagonist, antipsychotic haloperidol, significantly inhibits glutoxim- and molixan-induced Ca2+-response in peritoneal macrophages. These results indicate possible involvement of sigma-1 receptors in the signal cascade induced by glutoxim or molixan and leading to intracellular Ca2+ concentration increase in macrophages. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |