Flow cytometric analysis of the ERCC1, marker of DNA damage repair,in the tumor specimens embedded into paraffin blocks |
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| Authors: | T A Bogush E A Dudko A N Grishanina V T Zarkua E A Bogush A A Basharina B E Polotsky S A Tjulandin M M Davydov M I Davydov |
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| Institution: | 1.N.N. Blokhin Russian Cancer Research Center,Ministry of Health of the Russian Federation,Moscow,Russia;2.Faculty of Fundamental Medicine,Moscow State University,Moscow,Russia |
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| Abstract: | The differences in expression of ERCC1 were estimated between tumor specimens embedded into paraffin blocks and surgical biopsy specimens of non-small cell lung cancer as well as breast and ovarian cancers. Concordance or differences not higher than 20% were observed in 73% of the cases. The number of the cases with more significant differences in ERCC1 expression was less than 17%. The results show that ERCC1 detection in surgical biopsy specimens by flow cytometry is the more preferable method due to reduced preanalytical phase of the analysis. |
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