The lymphatic route. VIII. Distribution and plasma clearance of recombinant human interleukin-2 after SC administration with albumin in patients |
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Authors: | Velio Bocci Fabio Carraro Mario Zeuli Antonella Naldini Franco Calabresi |
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Affiliation: | (1) Institute of General Physiology of the University of Siena and Division of Medical Oncology I, Italy;(2) Istituto Regina Elena, Rome, Italy |
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Abstract: | It has been postulated that favouring the absorption of interleukin-2 via lymphatics rather than venous capillaries after subcutaneous adminstration may improve its therapeutic index. We have now evaluated in 12 cancer patients the plasma pharmacokinetic of interleukin-2 either dissolved in water or in 20% albumin solution with an internal cross-over after at least three days. Our data show that when albumin is present, the plasma concentrations of interleukin-2 versus time is increased and swelling at the injection sites is reduced. It remains to be seen whether efficacy improves during a prolonged treatment.Abbreviations AUC Area Under Plasma Curve - BRM Biological Response Modifiers - IFN Interferon - IL-2 Interleukin-2 - IV Intravenous - SC Subcutaneous - MU Megaunit |
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Keywords: | albumin interleukin 2 therapeutic index |
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