<Emphasis Type="Italic">ACE2</Emphasis> gene polymorphism and essential hypertension: an updated meta-analysis involving 11,051 subjects |
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Authors: | Na Lu Yang Yang Yibo Wang Yan Liu Gang Fu Dongmei Chen Hui Dai Xiaohan Fan Rutai Hui Yang Zheng |
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Institution: | (1) Department of Cardiology, Bethune First Hospital of Jilin University, 71 Xinmin Street, 130021 Changchun, Jilin, People’s Republic of China;(2) The Sino-German Laboratory of Molecular Medicine, Hypertension Division, Cardiovascular Institute, FuWai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, 167 Beilishi Road, 100037 Beijing, People’s Republic of China;(3) The People’s Hospital of Jilin Province, Changchun, China |
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Abstract: | The polymorphisms of angiotensin-converting enzyme 2 (ACE2) gene have been suggested to be linked to increase risk of essential hypertension in multiple populations. However, the
results are still debatable. To assess the association between ACE2 G8970A genetic polymorphism and essential hypertension, we conducted a meta-analysis of case–control studies across different
ethnicity. PubMed, Embase, CBM, Wanfang and VIP databases were searched, and a total of 11 separate studies in females and
nine separate studies in males met the inclusion criteria. Because ACE2 is on the X chromosome, data for each sex were analyzed separately. The selected studies contained 7,251 (4,472 females/2,779
males) hypertensive patients and 3,800 (2,161 females/1,639 males) normotensive controls. A statistically significant association
was observed between the G8970A gene polymorphism and essential hypertension risk in female hypertensive group in the recessive
genetic model (AA vs. GG+GA: P = 0.03, OR = 1.15, 95% CI = 1.02–1.30, P
heterogeneity = 0.40, I
2 = 5%, fixed-effects model). Although no association was shown between the frequency of the A allele and the genetic susceptibility
to essential hypertension in all male patients (A Allele: P = 0.38, OR = 1.10, 95% CI = 0.89–1.38, P
heterogeneity = 0.02, I
2 = 56%, random-effects model), we found that the relationship between carrier of A allele and the essential hypertension risk
in Han-Chinese male patients subgroup (A Allele: P = 0.006, OR = 1.21, 95% CI = 1.06–1.38, P
heterogeneity = 0.10, I
2 = 44%, fixed-effects model). The current meta-analysis provided solid evidence suggesting that ACE2 gene polymorphism G8790A was probably a genetic risk factor for essential hypertension across different ethnic populations
in female subjects and in Han-Chinese male subjects. |
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Keywords: | |
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