DXS539, a polymorphic DNA marker proximal of the fragile-X gene |
| |
| Authors: | J C F M Dreesen J A J M van den Hurk A P T Smits A M W van den Ouweland P W B Markslag B A van Oost |
| |
| Institution: | (1) Department of Human Genetics, University Hospital Nijmegen, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands;(2) DNA-Diagnostic Laboratory, Department of Human Genetics, University Hospital Nijmegen, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands |
| |
| Abstract: | We report a new polymorphic DNA marker (pJH89, DXS539) proximal to the fragile-X site. The pJH89 probe identifies a TaqI and a NcoI restriction fragment length polymorphism (combined heterozygosity of 42%) and is linked to the fragile-X locus with a maximal LOD score of 12 at 4 cM. Multipoint linkage analysis and physical mapping studies indicate that the pJH89 probe is located within the interval defined by the markers DXS369 and DXS548. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
