Phosphate transport in the duodenum and jejunum of goats and its adaptation by dietary phosphate and calcium |
| |
Authors: | Huber Korinna Walter Christina Schröder Bernd Breves Gerhard |
| |
Affiliation: | Department of Physiology, School of Veterinary Medicine, D-30173 Hannover, Germany. korinna.huber@tiho-hannover.de |
| |
Abstract: | Endogenous P(i) recycling is a characteristic feature of the P homeostasis in ruminants. A pronounced salivary P(i) secretion into the rumen is balanced by a high intestinal P(i) absorption and an almost complete renal P(i) reabsorption. In monogastric animals, the major P(i) transport mechanism across the apical membrane of the enterocyte is an Na(+)-dependent transport mediated by NaPi cotransporter type IIb. In ruminants, an Na(+)-, as well as an H(+)-dependent, P(i) transport system seems to exist in the small intestines. Therefore, morphological localization, type of ionic dependence, and ability to adapt to dietary P or Ca restriction of duodenal and jejunal P(i) transport were characterized in goats. In the duodenum, there was an H(+)-dependent, Na(+)-sensitive P(i) transport system that did not belong to the NaPi type II family and was not influenced by dietary P or Ca restriction. In contrast, in the jejunum, there was an Na(+)-dependent, H(+)-sensitive P(i) transport mainly mediated by NaPi IIb. P restriction stimulated the NaPi IIb protein expression, resulting in higher P(i) transport capacity. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|