Deoxyribonucleic Acid Polymerase of Rous Sarcoma Virus: Studies on the Mechanism of Double-Stranded Deoxyribonucleic Acid Synthesis |
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| Authors: | Anthony Faras Lois Fanshier Axel-Claude Garapin Warren Levinson J. Michael Bishop |
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| Affiliation: | aDepartment of Microbiology, University of California, San Francisco, California 94122 |
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| Abstract: | The deoxyribonucleic acid (DNA) polymerase of Rous sarcoma virus synthesizes both single- and double-stranded DNA, utilizing the ribonucleic acid (RNA) of the viral genome as the initial template. Results of pulse-chase experiments indicate that the single-stranded DNA serves as unconserved template and precursor for the synthesis of double-stranded DNA. The latter reaction is apparently initiated in association with the viral RNA and may involve a partially double-stranded intermediate form. |
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