Charybdotoxin blocks both Ca-activated K channels and Ca-independent voltage-gated K channels in rat brain synaptosomes |
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Authors: | MJ Schneider RS Rogowski BK Krueger MP Blaustein |
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Institution: | Department of Physiology, University of Maryland School of Medicine, Baltimore 21201. |
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Abstract: | Charybdotoxin (ChTX), a 4.3 kDa polypeptide toxin from the venom of the scorpion Leiurus quinquestriatus, blocks both a Ca-activated K channel (IC50 ≈ 15 nM) and a Ca-independent voltage-gated K channel (IC50 ≈ 40 nM) in rat brain synaptosomes. These results indicate that in this preparation ChTX is not specific for the Ca-activated K channel and suggest that there may be structural homology among the toxin-binding sites on various types of K channels. |
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Keywords: | Charybdotoxin K+ channel Synaptosome |
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