"hCG priming" effect in controlled ovarian stimulation through a long protocol |
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Authors: | Panagiotis Beretsos George A Partsinevelos Eleni Arabatzi Peter Drakakis Depy Mavrogianni Elli Anagnostou Kostas Stefanidis Aris Antsaklis and Dimitris Loutradis |
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Institution: | (1) 1st Department of Obstetrics and Gynaecology, Division of Human Reproduction, IVF Unit, Athens University Medical School, "Alexandra" Hospital, Athens, Greece |
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Abstract: | Background Recently, it has been demonstrated that, in patients down-regulated by GnRH analogues (GnRHa), a short-term pre-treatment
with recombinant LH (rLH), prior to recombinant FSH (rFSH) administration, increases the number of small antral follicle prior
to FSH stimulation and the yield of normally fertilized embryos. However, no data exist in the literature regarding the potential
beneficial effect of "hCG priming" in controlled ovarian hyperstimulation (COH) through a long GnRH-a protocol, which binds
the same receptor (LH/hCGR), though it is a much more potent compared to LH. The primary aims of this study were to assess
the effect of short-term pre-rFSH administration of hCG in women entering an ICSI treatment cycle on follicular development,
quality of oocytes and early embryo development. The secondary endpoints were to record the effects on endometrial quality
and pregnancy rate. |
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Keywords: | |
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