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"hCG priming" effect in controlled ovarian stimulation through a long protocol
Authors:Panagiotis Beretsos  George A Partsinevelos  Eleni Arabatzi  Peter Drakakis  Depy Mavrogianni  Elli Anagnostou  Kostas Stefanidis  Aris Antsaklis and Dimitris Loutradis
Institution:(1) 1st Department of Obstetrics and Gynaecology, Division of Human Reproduction, IVF Unit, Athens University Medical School, "Alexandra" Hospital, Athens, Greece
Abstract:

Background  

Recently, it has been demonstrated that, in patients down-regulated by GnRH analogues (GnRHa), a short-term pre-treatment with recombinant LH (rLH), prior to recombinant FSH (rFSH) administration, increases the number of small antral follicle prior to FSH stimulation and the yield of normally fertilized embryos. However, no data exist in the literature regarding the potential beneficial effect of "hCG priming" in controlled ovarian hyperstimulation (COH) through a long GnRH-a protocol, which binds the same receptor (LH/hCGR), though it is a much more potent compared to LH. The primary aims of this study were to assess the effect of short-term pre-rFSH administration of hCG in women entering an ICSI treatment cycle on follicular development, quality of oocytes and early embryo development. The secondary endpoints were to record the effects on endometrial quality and pregnancy rate.
Keywords:
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