Anti-inflammatory and immunosuppressive compounds from Tripterygium wilfordii |
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Authors: | Ma Jun Dey Moul Yang Hui Poulev Alexander Pouleva Reneta Dorn Ruth Lipsky Peter E Kennelly Edward J Raskin Ilya |
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Affiliation: | Biotech Center, Cook College, Rutgers University, 59 Dudley Road, New Brunswick, NJ 08901, USA. |
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Abstract: | The extract of Tripterygium wilfordii Hook F. (TwHF), which showed anti-inflammatory and immunosuppressive activities in human clinical trials for rheumatoid arthritis, was subjected to the activity-guided fractionation and spectroscopic characterization of bioactives. A tetrahydrofuran lignan, tripterygiol (1), and eight known compounds, all capable of suppressing pro-inflammatory gene expression were identified. Most of the pharmacological activity of the extract can be attributed to triptolide, its most abundant and active component, with some contribution from tripdiolide. |
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Keywords: | Tripterygium wilfordii Celastraceae Anti-inflammation Immunosuppression Tetrahydrofuran lignan Cyclooxygenase-2 (COX-2) Inducible nitric oxide synthase (iNOS) Interleukin-1β (IL-1β) Polymerase chain reaction (PCR) Triptolide, Tripdiolide |
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