Synthesis of poly-O-sulfated glycosides of 2,5-anhydro-D-mannitol |
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Authors: | Kuszmann János Medgyes Gábor Boros Sándor |
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Institution: | IVAX Drug Research Institute, H-1325 Budapest, PO Box 82, Hungary. janos.kuszmann@idri.hu |
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Abstract: | 2,5-Anhydro-3-O-beta-D-glucopyranosyl-; -3-O-alpha-L-idopyranosyl-; -3-O-alpha-D-arabinopyranosyl-; -3-O-alpha-L-arabinopyranosyl-; -3-O-beta-D-maltopyranosyl-; -3-O-beta-D-gentiobiopyranosyl-; -1,6-di-O-beta-D-glucopyranosyl-; -1,6-di-O-alpha-L-idopyranosyl-; -1-O-beta-D-maltopyranosyl-; -1,3,6-tri-O-beta-D-glucopyranosyl-; -1,6-di-O-beta-maltopyranosyl- and -1,6-di-O-beta-D-gentiobiopyranosyl-2,5-anhydro-D-mannitol as well as their poly-O-sulfated derivatives were synthesized. The IP3-IC50 values of their sodium and/or potassium salts were determined for structure-activity studies aiming at the synthesis of new, orally active antiasthmatic compounds. |
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Keywords: | 2 d-mannitol derivatives" target="_blank">5-Anhydro-d-mannitol derivatives Mono- di- tri- tetra- and pentasaccharides Poly-O-sulfated saccharides Antiasthmatic compounds |
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