Reduction of immunoreactivity of bovine serum albumin conjugated with polyethylene glycol(PEG) in relation to its esterase activity. |
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| Authors: | A Matsushima H Sasaki Y Kodera Y Inada |
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| Institution: | Toin University of Yokohama, Materials Science and Technology, Yokohama, Japan. |
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| Abstract: | Bovine serum albumin was modified with activated PEG2, 2,4-bisO-methoxypoly(ethylene glycol)]-6-chloro-s-triazine. The PEG-modified albumin, in which 15 out of the total 60 amino groups in the albumin molecule were coupled with activated PEG2, lost immunoreactivity towards anti-albumin serum and retained 63% of the esterase activity of native albumin. |
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